Ketamine Attenuates Acetylcholine-induced Contraction by Decreasing Myofilament Ca2+Sensitivity in Pulmonary Veins

Volume: 102, Issue: 3, Pages: 588 - 596
Published: Mar 1, 2005
Abstract
Background: The authors investigated the extent and cellular mechanisms by which the intravenous anesthetic ketamine alters acetylcholine-induced contraction in pulmonary veins (PVs). They tested the hypothesis that ketamine inhibits acetylcholine contraction in PVs. Methods: Canine PV rings with endothelium (E+) and without endothelium (E-) were isolated for measurement of isometric tension. The effects of ketamine (10 -5 null M∼10 -3 null M)...
Paper Details
Title
Ketamine Attenuates Acetylcholine-induced Contraction by Decreasing Myofilament Ca2+Sensitivity in Pulmonary Veins
Published Date
Mar 1, 2005
Volume
102
Issue
3
Pages
588 - 596
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