Small Interfering RNA Targeting Nuclear Factor Kappa B to Prevent Vein Graft Stenosis in Rat Models

Volume: 45, Issue: 6, Pages: 2553 - 2558
Published: Jul 1, 2013
Abstract
Intimal hyperplasia plays an important role in vein graft stenosis. Inflammatory injury, especially nuclear factor kappaB (NF-κB) gene activation, is highly involved in stenosis progression. We examined whether neointimal hyperplasia and vein graft stenosis could be inhibited by silencing the NF-κB gene with small interference RNA (siRNA).Sixty adult male Sprague-Dawley rats were randomly divided into a normal vein group, a vein graft group, a...
Paper Details
Title
Small Interfering RNA Targeting Nuclear Factor Kappa B to Prevent Vein Graft Stenosis in Rat Models
Published Date
Jul 1, 2013
Volume
45
Issue
6
Pages
2553 - 2558
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