The mouse liver displays daily rhythms in the metabolism of phospholipids and in the activity of lipid synthesizing enzymes

The circadian system involves central and peripheral oscillators regulating temporally biochemical processes including lipid metabolism; their disruption leads to severe metabolic diseases (obesity, diabetes, etc). Here, we investigated the temporal regulation of glycerophospholipid (GPL) synthesis in mouse liver, a well-known peripheral oscillator. Mice were synchronized to a 12:12 h light–dark (LD) cycle and then released to constant darkness...