RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

Volume: 111, Issue: 31, Pages: 11461 - 11466
Published: Aug 5, 2014
Abstract
AIDS remains incurable due to the permanent integration of HIV-1 into the host genome, imparting risk of viral reactivation even after antiretroviral therapy. New strategies are needed to ablate the viral genome from latently infected cells, because current methods are too inefficient and prone to adverse off-target effects. To eliminate the integrated HIV-1 genome, we used the Cas9/guide RNA (gRNA) system, in single and multiplex...
Paper Details
Title
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Published Date
Aug 5, 2014
Volume
111
Issue
31
Pages
11461 - 11466
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