Changes in liver and adipose tissue enzymes and lipogenic activities during the onset of hypothalamic obesity in mice

Introduction of hyperphagia by injection of aurothioglucose resulted in rapid deposition of tissue lipid. The changes in tissue enzyme levels and in vivo rates of lipogenesis from U-14C glucose were measured at 2, 4, and 8-week intervals post-aurothioglucose injection. Rapid increases of both enzyme activity and in vivo lipogenesis were observed during the onset of obesity. The elevated levels of adipose tissue enzyme activities were restored to...