The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson's disease, schizophrenia, depression, autism, and chronic fatigue syndrome.While the majority of patients with multiple sclerosis appear to have widespread mitochondrial dysfunction and impaired...