Caramiphen edisylate as adjunct to standard therapy attenuates soman-induced seizures and cognitive deficits in rats
Abstract
The progression of epileptiform activity following soman (GD) exposure is characterized by a period of excessive cholinergic activity followed by excessive glutamatergic activity resulting in status epilepticus, which may lead to neuropathological damage and behavioral deficits. Caramiphen edisylate is an anticholinergic drug with antiglutamatergic properties, which conceptually may be a beneficial therapeutic approach to the treatment of nerve...
Paper Details
Title
Caramiphen edisylate as adjunct to standard therapy attenuates soman-induced seizures and cognitive deficits in rats
Published Date
Jul 1, 2014
Volume
44
Pages
89 - 104
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