Role of IL‐10 in Inflammation: Studies Using Cytokine Knockout Mice^a

: Interleukin‐10 (IL‐10) inhibits the synthesis of proinflammatory cytokines known to be involved in fever, including IL‐1, IL‐6, and tumor necrosis factor‐α. We hypothesized that IL‐10 modulates lipopolysaccharide (LPS)‐induced fever in mice. Body temperature was measured by biotelemetry. Swiss Webster mice injected with recombinant murine IL‐10 (rmuIL‐10) were resistant to fever induced by a low dose of LPS (100 μg/kg, ip) and to the...