Peripheral Adiposity Exhibits an Independent Dominant Antiatherogenic Effect in Elderly Women

Published on Apr 1, 2003in Circulation23.054
· DOI :10.1161/01.CIR.0000057974.74060.68
László B. Tankó38
Estimated H-index: 38
(AAU: Aalborg University),
Yu Z. Bagger28
Estimated H-index: 28
(AAU: Aalborg University)
+ 2 AuthorsClaus Christiansen1
Estimated H-index: 1
(AAU: Aalborg University)
Background— Although several lines of evidence point to an atherogenic role of central fat mass (CFM), few data are available to address the specific role played by peripheral fat mass (PFM). Methods and Results— This study was a cross-sectional analysis of 1356 women aged 60 to 85 years. Study variables were physical measures, CFM and PFM measured by DEXA, aortic calcification (AC) graded on lateral radiographs, lipid and glucose metabolites, blood pressure, and information on lifestyle factors and coronary disease. Peripheral fat mass showed independent negative correlation with both atherogenic metabolic risk factors and AC (P<0.001). The most severe insulin resistance-dyslipidemic syndrome and AC (score 5.10±0.76) was found in women with high central fat percentage (CF%, 21.7±0.2%) and low peripheral fat percentage (PF%, 18.3±0.2%, n=48). The least severe AC (score 2.45±0.31) was found in obese women with high CF% (21.6±0.1%) and high PF% (27.3±0.14%, n=112). The insulin resistance-dyslipidemic syndro...
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