Design and development of therapies using chimeric antigen receptor‐expressing T cells
Abstract
Investigators developed chimeric antigen receptors (CARs) for expression on T cells more than 25 years ago. When the CAR is derived from an antibody, the resultant cell should combine the desirable targeting features of an antibody (e.g. lack of requirement for major histocompatibility complex recognition, ability to recognize non-protein antigens) with the persistence, trafficking, and effector functions of a T cell. This article describes how...
Paper Details
Title
Design and development of therapies using chimeric antigen receptor‐expressing T cells
Published Date
Dec 13, 2013
Journal
Volume
257
Issue
1
Pages
107 - 126
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Notes
History