Functional factor XIII-A is exposed on the stimulated platelet surface
Abstract
Factor XIII (FXIII) stabilizes thrombi against fibrinolysis by cross-linking α2-antiplasmin (α2AP) to fibrin. Cellular FXIII (FXIII-A) is abundant in platelets, but the extracellular functions of this pool are unclear because it is not released by classical secretion mechanisms. We examined the function of platelet FXIII-A using Chandler model thrombi formed from FXIII-depleted plasma. Platelets stabilized FXIII-depleted thrombi in a...
Paper Details
Title
Functional factor XIII-A is exposed on the stimulated platelet surface
Published Date
Dec 18, 2014
Journal
Volume
124
Issue
26
Pages
3982 - 3990
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