Complexes of hydroxy(thio)pyrone and hydroxy(thio)pyridinone with Zn(ii) and Mo(vi). Thermodynamic stability and insulin-mimetic activity

The development of metal-containing pharmaceuticals as insulin-mimetics has been the object of recent worldwide research. We have examined a series of zinc(ii) and molybdenum(vi) complexes with model O,S-donor ligands (thiomaltol and 1,2-dimethyl-3-hydroxypyridine-4-thione (DMHTP)) and the corresponding O,O-analogues (maltol and DMHP) for their insulin-mimetic activity. Aimed at getting structure-activity relationships, some physical-chemical...