Transcript-RNA-templated DNA recombination and repair

Endogenous RNA transcripts are shown to mediate recombination with yeast chromosomal DNA; as the level of RNAs in the nucleus is quite high, these results may open up new understanding of the plasticity of repair and genome instability mechanisms. As the name implies, DNA repair by homologous recombination generally is thought of as occurring between two DNA molecules. However, it has been shown that RNA can also be used in artificial settings....