Accessibility and the developmental regulation of V(D)J recombination
Abstract
Antigen receptor genes are assembled from their component gene segments by a highly regulated series of site-specific DNA recombination reactions known as V(D)J recombination. Proteins encoded by the RAG1 and RAG2 genes are responsible for the recognition and double-stranded cleavage of a highly conserved DNA sequence flanking all rearranging gene segments. It remains uncertain how this common lymphoid recombinase is targeted to distinct loci in...
Paper Details
Title
Accessibility and the developmental regulation of V(D)J recombination
Published Date
Jun 1, 1997
Journal
Volume
9
Issue
3
Pages
161 - 170
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