Original paper
Small molecule–triggered Cas9 protein with improved genome-editing specificity
Abstract
Directly modulating the activity of genome-editing proteins has the potential to increase their specificity by reducing activity following target locus modification. We developed Cas9 nucleases that are activated by the presence of a cell-permeable small molecule by inserting an evolved 4-hydroxytamoxifen-responsive intein at specific positions in Cas9. In human cells, conditionally active Cas9s modify target genomic sites with up to 25-fold...
Paper Details
Title
Small molecule–triggered Cas9 protein with improved genome-editing specificity
Published Date
Apr 6, 2015
Journal
Volume
11
Issue
5
Pages
316 - 318
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Notes
History