Efficient genome editing in zebrafish using a CRISPR-Cas system
Abstract
In bacteria, foreign nucleic acids are silenced by clustered, regularly interspaced, short palindromic repeats (CRISPR)--CRISPR-associated (Cas) systems. Bacterial type II CRISPR systems have been adapted to create guide RNAs that direct site-specific DNA cleavage by the Cas9 endonuclease in cultured cells. Here we show that the CRISPR-Cas system functions in vivo to induce targeted genetic modifications in zebrafish embryos with efficiencies...
Paper Details
Title
Efficient genome editing in zebrafish using a CRISPR-Cas system
Published Date
Mar 1, 2013
Journal
Volume
31
Issue
3
Pages
227 - 229
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History