Asymptomatic carriage of toxigenic Clostridium difficile by hospitalized patients

Published on Oct 1, 2013in Journal of Hospital Infection3.70
· DOI :10.1016/j.jhin.2013.07.002
Dubert M. Guerrero7
Estimated H-index: 7
(Case Western Reserve University),
J.C. Becker1
Estimated H-index: 1
+ 4 AuthorsCurtis J. Donskey46
Estimated H-index: 46
(Case Western Reserve University)
Summary Asymptomatic carriage of Clostridium difficile is common in hospitals, but the risk for transmission by carriers is unclear. In this point prevalence culture survey of asymptomatic hospitalized patients, 18 of 149 (12%) were carriers of toxigenic C. difficile . By comparison with C. difficile infection (CDI) patients, the prevalence of skin and/or environmental contamination was significantly lower in asymptomatic carriers (3/18, 17% versus 5/6, 83%; P  = 0.007), but carriers outnumbered CDI patients in the hospital by a factor of 3 to 1. These data suggest that asymptomatic carriers have the potential to contribute to C. difficile transmission in hospitals.
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  • Citations (46)
#1A. Sarah Walker (NIHR: National Institute for Health Research)H-Index: 44
#2David W. Eyre (NIHR: National Institute for Health Research)H-Index: 23
Last.Mark H. Wilcox (University of Leeds)H-Index: 75
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#1Jon P. Furuno (UMB: University of Maryland, Baltimore)H-Index: 25
#2Jessina C. McGregor (UMB: University of Maryland, Baltimore)H-Index: 23
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#1Kyung-Hee Kim (UM: University of Michigan)H-Index: 4
#2Robert Fekety (UM: University of Michigan)H-Index: 30
Last.D. Waters (UM: University of Michigan)H-Index: 1
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Cited By46
#1Monique J. T. Crobach (LEI: Leiden University)H-Index: 6
#2Jonathan Vernon (Leeds Teaching Hospitals NHS Trust)H-Index: 6
Last.Ed J. Kuijper (LEI: Leiden University)H-Index: 72
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#1Natalia Blanco (UMB: University of Maryland, Baltimore)H-Index: 2
#2Surbhi Leekha (UMB: University of Maryland, Baltimore)H-Index: 13
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