Design of industrial crystallization of interferon gamma: Phase diagrams and solubility curves
Abstract
Phase diagrams and solubility curves for engineering of crystallization for interferon gamma have been developed by small scale precipitation and crystallization experiments. A scale up was carried out to proof the accuracy and the suitability of the created phase diagram with sodium sulfate for bulk crystallization. To provide nucleation and a high yield the operating point was chosen at a protein concentration of 6 mg/mL and a sodium sulfate...
Paper Details
Title
Design of industrial crystallization of interferon gamma: Phase diagrams and solubility curves
Published Date
Apr 1, 2015
Journal
Volume
126
Pages
341 - 348
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