Evaluation of in vivo-in vitro release of dexamethasone from PLGA microspheres.

Volume: 127, Issue: 2, Pages: 137 - 145
Published: Apr 21, 2008
Abstract
Two poly(lactic-co-glycolic acid) (PLGA) microsphere formulations, with different polymer molecular weights were investigated to determine whether an in vitro and in vivo relationship could be established for dexamethasone release. A USP apparatus 4 was used for in vitro testing. The in vivo release kinetics and pharmacodynamic effects of dexamethasone were evaluated using a Sprague Dawley rat model. The in vitro release from both formulations...
Paper Details
Title
Evaluation of in vivo-in vitro release of dexamethasone from PLGA microspheres.
Published Date
Apr 21, 2008
Volume
127
Issue
2
Pages
137 - 145
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