Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Volume: 110, Issue: 21, Pages: 8690 - 8695
Published: May 21, 2013
Abstract
Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an important therapeutic target. Allosteric IN inhibitors (ALLINIs) that engage the IN dimer interface at the binding site for the host protein lens epithelium-derived growth factor (LEDGF)/transcriptional coactivator p75 are an emerging class of small molecule antagonists. Consistent with the inhibition of a multivalent drug target, ALLINIs display steep...
Paper Details
Title
Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Published Date
May 21, 2013
Volume
110
Issue
21
Pages
8690 - 8695
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