Cyclic Nucleotide-Gated Cation Channels

Cyclic nucleotide-gated (CNG) channels comprise an extended family of cation channels that are directly activated by the binding of cGMP or cAMP. These channels are abundantly expressed in visual and olfactory neurons, where they play important roles in sensory signal transduction. Recent studies have shown that CNG channels are also present in many nonsensory cell types. The major function of CNG channels probably is to provide a...