Mitochondrial chloride channels – What are they for?

This minireview focuses on observation of the properties, functional significance, and modulation of single chloride channels in the mitochondrial inner membrane using two electrophysiological methods – the patch‐clamp and bilayer lipid membrane methods. Measurements of parameters such as conductance, Cl − /K + selectivity, voltage or pH dependence as well as their modulation by endogenous and exogenous compounds using individual mitochondrial...