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Weight Lifting and Aortic Dissection: More Evidence for a Connection

Published on Jan 1, 2007in The Cardiology1.56
· DOI :10.1159/000094530
Ioannis Hatzaras5
Estimated H-index: 5
(Yale University),
Maryann Tranquilli20
Estimated H-index: 20
(Yale University)
+ 3 AuthorsJohn A. Elefteriades54
Estimated H-index: 54
(Yale University)
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Abstract
Background/Aims: In 2003, we reported on a small number of patients in whom acute aortic dissection appeared to be causally related to intense weight lifting. If additional cases co
  • References (5)
  • Citations (109)
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References5
Newest
George J. Koullias13
Estimated H-index: 13
,
Raj Modak3
Estimated H-index: 3
(Yale University)
+ 3 AuthorsJohn A. Elefteriades54
Estimated H-index: 54
Objective The human ascending aorta becomes markedly prone to rupture and dissection at a diameter of 6 cm. The mechanical substrate for this malignant behavior is unknown. This investigation applied engineering analysis to human ascending aortic aneurysms and compared their structural characteristics with those of normal aortas. Methods We measured the mechanical characteristics of the aorta by direct epiaortic echocardiography at the time of surgery in 33 patients with ascending aortic aneurys...
Published on Aug 1, 2005in Scientific American1.95
John A. Elefteriades54
Estimated H-index: 54
Published on Dec 3, 2003in JAMA51.27
John A. Elefteriades54
Estimated H-index: 54
,
Ioannis Hatzaras5
Estimated H-index: 5
+ 5 AuthorsPaul G. Barash34
Estimated H-index: 34
To the Editor: It is unclear whether aortic dissection is associated with high-intensity strength training. Methods. From our Yale University aortic database, and from outside cases brought to our attention after lay press reports of our aortic research, we identified and reviewed case materials of 5 patients who experienced acute dissection of the ascending aorta in the setting of high-intensity weight training or other strenuous exercise. Results. The 5 patients ranged in age between 19 and 53...
Published on Nov 1, 1998in The Annals of Thoracic Surgery3.92
David L.S. Morales40
Estimated H-index: 40
(Yale University),
Jacquelyn A. Quin4
Estimated H-index: 4
(Yale University)
+ 3 AuthorsJohn A. Elefteriades54
Estimated H-index: 54
(Yale University)
Abstract Background . Aortic fenestration is used clinically to treat organ ischemia in acute descending aortic dissection. However, fenestration has not been studied experimentally. This study does so using an animal model. Methods . Descending aortic dissection was created in six dogs, with subsequent fenestration of the infrarenal aorta. Blood flow (femoral, cephalic, and renal), blood pressure (femoral and carotid), and aortic distensibility were measured at baseline, after dissection, and a...
Published on Apr 1, 1990in The Annals of Thoracic Surgery3.92
Christian de Virgilio27
Estimated H-index: 27
(UCLA Medical Center),
Ronald J. Nelson13
Estimated H-index: 13
(UCLA Medical Center)
+ 4 AuthorsJohn M. Robertson18
Estimated H-index: 18
(UCLA Medical Center)
Abstract We report 4 cases of ascending aortic dissection in patients with long histories of weight lifting. In 2 of the patients, the initial symptoms of dissection developed while they were lifting weights. Two patients had a history of hypertension and 2 had previously used anabolic steroids. All 4 were successfully treated surgically. Histopathology showed aortic medial changes in all 4. We believe that the hemodynamic stresses of weight lifting, namely, a rapid increase in systemic arterial...
Cited By109
Newest
Published on Jun 1, 2019in Cardiovascular Engineering and Technology1.78
Elie Salameh (AUB: American University of Beirut), Charbel Saade6
Estimated H-index: 6
(AUB: American University of Beirut),
Ghanem F. Oweis8
Estimated H-index: 8
(AUB: American University of Beirut)
Purpose In a curved vessel such as the aortic arch, the velocity profile closer to the aortic root is normally skewed towards the inner curvature wall, while further downstream along the curve, the velocity profile becomes skewed towards the outer wall. In an aortic dissection (AD) disease, blood velocities in the true lumen (TL) and false lumen (FL) are hypothesized to depend on the proximity of the entry tear to the root of aortic arch. Faster velocity in the FL can lead to higher hemodynamic ...
Published on Jun 1, 2019in Heart Lung and Circulation2.08
Sharon Kay (Kolling Institute of Medical Research), Benjamin M. Moore4
Estimated H-index: 4
(USYD: University of Sydney)
+ 5 AuthorsDavid S. Celermajer87
Estimated H-index: 87
(USYD: University of Sydney)
Background Prompted by a cluster of observations concerning ascending aortic pathology in elite rugby players, we assessed over 150 asymptomatic predominantly retired players with echocardiography, aiming to document the prevalence and severity of ascending aortic dilatation and/or anterior aortic effacement, both ‘risk factors’ for potentially catastrophic aortic complications. Methods Rugby players (at least 5 years of high level competitive rugby) were classified as elite (national, state or ...
Published on Apr 3, 2019in Expert Review of Cardiovascular Therapy
Carlijn G.E. Thijssen (EUR: Erasmus University Rotterdam), Lidia R. Bons2
Estimated H-index: 2
(EUR: Erasmus University Rotterdam)
+ 5 AuthorsJolien W. Roos-Hesselink47
Estimated H-index: 47
(EUR: Erasmus University Rotterdam)
ABSTRACTIntroduction: Current guidelines recommend patients with thoracic aortic disease (TAD) including inherited aortopathies to avoid heavy exercise. However, evidence supporting the negative advice on exercise is scarce. We aimed to provide an up-to-date systematic review of the available evidence on risks and benefits of exercise and sports participation in TAD patients.Areas covered: A systematic search was performed in Medline, Embase and Web of Science: thoracic aortic aneurysm or thorac...
Published on Feb 1, 2019in Biomechanics and Modeling in Mechanobiology2.83
Matthew R. Bersi11
Estimated H-index: 11
(Yale University),
Chiara Bellini10
Estimated H-index: 10
(Yale University)
+ 1 AuthorsStéphane Avril27
Estimated H-index: 27
(University of Lyon)
We recently developed an approach to characterize local nonlinear, anisotropic mechanical properties of murine arteries by combining biaxial extension–distension testing, panoramic digital image correlation, and an inverse method based on the principle of virtual power. This experimental–computational approach was illustrated for the normal murine abdominal aorta assuming uniform wall thickness. Here, however, we extend our prior approach by adding an optical coherence tomography (OCT) imaging s...
Sina Stock4
Estimated H-index: 4
,
Salah A Mohamed14
Estimated H-index: 14
,
Hh Sievers34
Estimated H-index: 34
Bicuspid aortic valve related aortopathy is known to significantly increase the risk for catastrophic aortic events and, therefore, represents a considerable health burden. Albeit of ongoing research in this field including genetic, molecular, hemodynamic and morphologic aspects, bicuspid aortic valve related aortopathy still represents an imperfectly understood disorder. This lack in knowledge results in a lack of consistency considering different therapeutic approaches. Recent studies have pro...
Published on Jan 1, 2019
Bulat A. Ziganshin14
Estimated H-index: 14
(Yale University),
John A. Elefteriades54
Estimated H-index: 54
(Yale University)
Aortic dissection is the most common and highly lethal aortic emergency. Multiple studies have described the epidemiology, natural history, and management strategies of aortic dissection; however, few studies have addressed the question—What triggers the aorta to dissect? It is generally considered that aortic dissection is a random event that can occur at any day and point in time. However, there is evidence to suggest that aortic dissection is indeed not random; rather, we now believe that aor...
Published on Jan 1, 2019
Alan C. Braverman23
Estimated H-index: 23
(WashU: Washington University in St. Louis),
Alan C. Braverman
Thoracic aortic aneurysm disease is an important cause of morbidity and mortality. Recognizing the specific disorder responsible for the condition informs management, including screening of first-degree relatives, imaging strategies, and determining the timing of prophylactic surgery or endovascular repair. Pharmacologic therapy typically involves beta adrenergic blocking agents, which slow the heart rate and lower blood pressure. Hemodynamic benefits of beta blockers may lessen stress on the ao...
Published on Dec 21, 2018in Journal of the Royal Society Interface3.22
Hossein Ahmadzadeh7
Estimated H-index: 7
(Yale University),
M. K. Rausch (University of Texas at Austin), D HumphreyJay56
Estimated H-index: 56
(Yale University)
Accumulated glycosaminoglycans (GAGs) can sequester water and induce swelling within the intra-lamellar spaces of the medial layer of an artery. It is increasingly believed that stress concentrations caused by focal swelling can trigger the damage and delamination that is often seen in thoracic aortic disease. Here, we present computational simulations using an extended smoothed particle hydrodynamics approach to examine potential roles of pooled GAGs in initiating and propagating intra-lamellar...
Published on Nov 1, 2018in Pm&r1.90
Roberto S. Miyasato1
Estimated H-index: 1
(USP: University of São Paulo),
Carla Silva-Batista6
Estimated H-index: 6
(USP: University of São Paulo)
+ 6 AuthorsHélcio Kanegusuku7
Estimated H-index: 7
(USP: University of São Paulo)
Abstract Background Patients with Parkinson disease (PD) present cardiovascular autonomic dysfunction that impairs blood pressure control. However, cardiovascular responses during resistance exercise are unknown in these patients. Objective To investigate cardiovascular responses during resistance exercise performed with different muscle masses in patients with PD. Design Prospective, repeated-measures. Setting Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University o...
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