Amino acid substitution matrices from an information theoretic perspective
Abstract
Protein sequence alignments have become an important tool for molecular biologists. Local alignments are frequently constructed with the aid of a “substitution score matrix” that specifies a score for aligning each pair of amino acid residues. Over the years, many different substitution matrices have been proposed, based on a wide variety of rationales. Statistical results, however, demonstrate that any such matrix is implicitly a “log-odds”...
Paper Details
Title
Amino acid substitution matrices from an information theoretic perspective
Published Date
Jun 1, 1991
Journal
Volume
219
Issue
3
Pages
555 - 565
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