Characterization of hepatitis virus B isolated from a multi-drug refractory patient
Abstract
Prolonged treatment of chronic hepatitis B (CHB) with nucleoside analogues (NAs) almost invariably engenders viral resistance, and sequential NAs monotherapy can promote multi-drug resistance. This study aimed to investigate the molecular characteristics and the mutation profile of multi-drug resistant hepatitis B virus (HBV). The complete genome of HBV isolated from a multi-drug refractory patient was amplified and cloned, and 22 clones were...
Paper Details
Title
Characterization of hepatitis virus B isolated from a multi-drug refractory patient
Published Date
Jan 1, 2011
Journal
Volume
155
Issue
1
Pages
254 - 258
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