Interleukin-6 Depletion Selectively Improves Hepatic Insulin Action in Obesity
Abstract
Obesity and insulin resistance are considered chronic inflammatory states, in part because circulating IL-6 is elevated. Exogenous IL-6 can induce hepatic insulin resistance in vitro and in vivo. The importance of endogenous IL-6, however, to insulin resistance of obesity is unresolved. To test the hypothesis that IL-6 contributes to the inflammation and insulin resistance of obesity, IL-6 was depleted in Lepob mice by injection of...
Paper Details
Title
Interleukin-6 Depletion Selectively Improves Hepatic Insulin Action in Obesity
Published Date
Aug 1, 2005
Journal
Volume
146
Issue
8
Pages
3417 - 3427
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