Diorganotin(IV) antitumor agent. (C2H5)2SnCl2 (phen)/nucleotides aqueous and solid-state coordination chemistry and its DNA binding studies

This contribution reports a solution and solid-state study of the aqueous nucleotide coordination chemistry of the dieihyltin(IV) antitumor agent, (C2H5)2SnC12(phen). [trans-en2OS(η-H2] (CF3SO3)2, a versatile 1H NMR probe for biomolecules, is first used to investigate the interaction of (C2H5)2SnC12(phen) with DGMP in neutral aqueous solution, and then the synthesis of mixed-ligands complexes formulated as (C2Hn5)SnC1(phenXNu) (Nu is nucleotide)...