Lack of dopamine D4 receptor affinity contributes to the procognitive effect of lurasidone
Abstract
We previously demonstrated among several antipsychotics exhibiting potent dopamine D2 receptor antagonism that only lurasidone, (1R,2S,3R,4S)-N-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl]-1-cyclohexylmethyl]-2,3-bicyclo[2.2.1] heptanedicarboximide hydrochloride, improved performance in the object retrieval detour (ORD) task by marmosets. The mechanisms by which only lurasidone causes enhancements in cognitive function have not...
Paper Details
Title
Lack of dopamine D4 receptor affinity contributes to the procognitive effect of lurasidone
Published Date
Mar 1, 2014
Journal
Volume
261
Pages
26 - 30
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