Role of non-esterified fatty acids in the pathogenesis of type 2 diabetes mellitus.
Abstract
Over 30 years after the original description of Randle's cycle, the mechanisms by which elevated circulating non-esterified fatty acids might be causally related to glucose intolerance in Type 2 diabetes mellitus remain uncertain. This review examines the evidence that elevated plasma NEFA can inhibit glucose-stimulated insulin secretion by pancreatic beta-cells and impair glucose- and insulin-stimulated glucose disposal by peripheral tissues....
Paper Details
Title
Role of non-esterified fatty acids in the pathogenesis of type 2 diabetes mellitus.
Published Date
May 1, 1998
Journal
Volume
15
Issue
5
Pages
360 - 366
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