Pregnane X Receptor-Dependent Induction of the CYP3A4 Gene by o,p′-1,1,1,-Trichloro-2,2-Bis (p-Chlorophenyl)ethane

CYP3A4, the predominant cytochrome P450 (P450) expressed in human liver and intestine, contributes to the metabolism of approximately half the drugs in clinical use today. CYP3A4 catalyzes the 6β-hydroxylation of a number of steroid hormones and is involved in the bioactivation of environmental procarcinogens. The expression of CYP3A4 is affected by several stimuli, including environmental factors such as insecticides and pesticides. The...