Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
Abstract
Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that, for 2-Arachidonoylglycerol (2-AG), is mediated by monoacylglycerol lipase (MAGL). The piperidine carbamate, 4-nitrophenyl- 4-(dibenzo[d] [1,3]dioxol-5-yl (hydroxy) methyl) piperidine- 1-carboxylate (JZL184), is a drug that inhibits MAGL and presents high potency and selectivity. Thus, JZL184 increases the levels of 2-AG, an endocannabinoid that acts on the CB1 and...
Paper Details
Title
Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
Published Date
Oct 25, 2013
Journal
Volume
8
Issue
10
Pages
e77706 - e77706
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