Label-Free Sensing of Adenosine Based on Force Variations Induced by Molecular Recognition
Abstract
We demonstrate a simple force-based label-free strategy for the highly sensitive sensing of adenosine. An adenosine ssDNA aptamer was bound onto an atomic force microscopy (AFM) probe by covalent modification, and the molecular-interface adsorption force between the aptamer and a flat graphite surface was measured by single-molecule force spectroscopy (SMFS). In the presence of adenosine, the molecular recognition between adenosine and the...
Paper Details
Title
Label-Free Sensing of Adenosine Based on Force Variations Induced by Molecular Recognition
Published Date
Mar 19, 2015
Journal
Volume
5
Issue
1
Pages
85 - 97
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