Original paper
Pathological neoangiogenesis depends on oxidative stress regulation by ATM
Abstract
The ataxia telangiectasia mutated (ATM) kinase, a master regulator of the DNA damage response (DDR), acts as a barrier to cellular senescence and tumorigenesis. Aside from DDR signaling, ATM also functions in oxidative defense. Here we show that Atm in mice is activated specifically in immature vessels in response to the accumulation of reactive oxygen species (ROS). Global or endothelial-specific Atm deficiency in mice blocked pathological...
Paper Details
Title
Pathological neoangiogenesis depends on oxidative stress regulation by ATM
Published Date
Jul 15, 2012
Journal
Volume
18
Issue
8
Pages
1208 - 1216
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Notes
History