Antagonism of sarin poisoning in rats and guinea pigs by atropine, oximes, and mecamylamine
Abstract
Intramuscular atropine-oxime therapy for sarin poisoning in rats and guinea pigs was evaluated. Injection of 7.5 mg/kg of pyridinium aldoxime methochloride (2-PAMCl) plus 16 mg/kg of atropine 1 min after poisoning rats with sarin subcutaneously raised the LD50 of the organophosphorous compound 2.5-fold. Toxogonin (7.5 mg/kg) gave somewhat less protection when substituted for 2-PAMCl. Atropine-oxime therapy was more successful in sarin-poisoned...
Paper Details
Title
Antagonism of sarin poisoning in rats and guinea pigs by atropine, oximes, and mecamylamine
Published Date
Jan 1, 1970
Volume
16
Issue
1
Pages
40 - 47
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