Clioquinol, a lipophilic Zn2+ chelator, augments and attenuates the cytotoxicity of H2O2: a bell-shaped response curve of the effects of the drug

Clioquinol, a lipophilic Zn2+ chelator, has emerged as a potential novel therapeutic agent for several diseases such as cancer and Alzheimer's disease. Clioquinol has different effects on the intracellular Zn2+ concentrations in rat thymocytes, depending on its concentration and extracellular Zn2+ levels. In this study, we examined the effect of clioquinol on cells under oxidative stress induced by hydrogen peroxide (H2O2) by using a...