Lymphatic vascular integrity is disrupted in type 2 diabetes due to impaired nitric oxide signalling

Lymphatic vessel dysfunction is an emerging component of metabolic diseases and can lead to tissue lipid accumulation, dyslipidaemia, and oedema. While lymph leakage has been implicated in obesity and hypercholesterolaemia, whether similar lymphatic dysfunction exists in diabetes has not been investigated.To measure the lymphatic integrity of transgenic mice, we developed a new assay that quantifies the solute permeability of murine collecting...