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PASSIONFLOWER IN THE TREATMENT OF GENERALIZED ANXIETY: A PILOT DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL WITH OXAZEPAM

Published on Oct 1, 2001in Journal of Clinical Pharmacy and Therapeutics 2.17
· DOI :10.1046/j.1365-2710.2001.00367.x
Shahin Akhondzadeh46
Estimated H-index: 46
(Tehran University of Medical Sciences),
Hamid Reza Naghavi9
Estimated H-index: 9
(Tehran University of Medical Sciences)
+ 3 AuthorsM Khani6
Estimated H-index: 6
Cite
Abstract
Objective: Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder. Methods: The study was performed on 36 out-patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial. Results: Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam. Conclusion: The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage. A large-scale trial is justified.
  • References (26)
  • Citations (136)
Cite
References26
Newest
Published on Jan 1, 2010
Laura Campbell-Sills23
Estimated H-index: 23
,
Timothy A. Brown52
Estimated H-index: 52
Since its inception as a diagnostic category in 1980, the definitional criteria for generalized anxiety disorder (GAD) have been revised substantially in each edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM). In DSM-III (American Psychiatric Association, 1980), GAD was a residual category (i.e., diagnosis was permitted only if criteria were not met for any other Axis I disorder); it was defined as the presence of generalized, persistent anxiety (continuous for a period ...
Published on Feb 1, 2001in Current Opinion in Pharmacology 5.20
Hanns Möhler11
Estimated H-index: 11
(EPFL: École Polytechnique Fédérale de Lausanne),
Florence Crestani23
Estimated H-index: 23
(EPFL: École Polytechnique Fédérale de Lausanne),
Uwe Rudolph56
Estimated H-index: 56
(EPFL: École Polytechnique Fédérale de Lausanne)
Abstract The GABA A receptor is a pluripotent drug target mediating anxiolytic, sedative, anticonvulsant, muscle relaxant and amnesic activity. These drug actions have now been attributed to defined receptor subtypes. Thus, precise guidelines are available for the development of novel drugs with more selective action and less side effects than those currently in clinical use.
Published on Apr 1, 1999in Brain Research Reviews
Ashok K. Mehta20
Estimated H-index: 20
(University of Texas Health Science Center at San Antonio),
Maharaj K. Ticku43
Estimated H-index: 43
(University of Texas Health Science Center at San Antonio)
Abstract Recent advances in molecular biology and complementary information derived from neuropharmacology, biochemistry and behavior have dramatically increased our understanding of various aspects of GABA A receptors. These studies have revealed that the GABA A receptor is derived from various subunits such as α 1 –α 6 , β 1 –β 3 , γ 1 –γ 3 , δ, e, π, and ρ 1–3 . Furthermore, two additional subunits (β 4 , γ 4 ) of GABA A receptors in chick brain, and five isoforms of the ρ-subunit in the reti...
Published on Jan 1, 1999in Journal of Psychopharmacology 4.22
Miriam Z. Mintzer21
Estimated H-index: 21
(JHUSOM: Johns Hopkins University School of Medicine),
Roland R. Griffiths70
Estimated H-index: 70
(JHUSOM: Johns Hopkins University School of Medicine)
Zolpidem is an imidazopyridine hypnotic with preferential binding affnity for the o1-benzodiazepine (BZD) receptor. The present double-blind, placebo-controlled study evaluated the effects of orally administered zolpidem (15 mg/70 kg) on specific memory functions in 16 healthy volunteers using a battery of word and picture memory tasks. Relative to placebo, zolpidem significantly impaired memory for material presented after drug administration when memory was assessed directly by referring subje...
Published on Dec 1, 1998in Pharmacological Research 5.57
Shahin Akhondzadeh46
Estimated H-index: 46
(Tehran University of Medical Sciences),
Trevor Stone59
Estimated H-index: 59
(Glas.: University of Glasgow)
Abstract We have recently reported a new protocol for inducing long-term depression through activation of GABA A receptors in the hippocampal slices. This long-term depression is reversed by bicuculline and potentiated by neurosteroids such as alphaxalone. It was also shown that glutamate receptor activity or extracellular calcium are not involved in the induction of this type of long-term depression. The present study investigated the possible relation between muscimol-induced long-term depress...
Published on Nov 1, 1998in Pharmacology, Biochemistry and Behavior 2.77
Craig R. Rush9
Estimated H-index: 9
(UMMC: University of Mississippi Medical Center)
Abstract Zolpidem, an imidazopyridine that purportedly binds selectively to certain GABA A receptor subtypes, is the most commonly prescribed hypnotic. The present article critically reviewed the extant experimental literature to determine whether the behavioral pharmacologic profile of zolpidem also differs from that of benzodiazepines. Specific topics that are reviewed include: 1) reinforcing effects and abuse potential, 2) discriminative-stimulus effects, 3) subject-rated drug effects, 4) per...
Published on Nov 1, 1997in Behavioural Pharmacology 1.79
Miriam Z. Mintzer21
Estimated H-index: 21
,
J M Frey1
Estimated H-index: 1
(Astra)
+ 1 AuthorsRoland R. Griffiths70
Estimated H-index: 70
The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo
Published on Sep 1, 1995in European Neuropsychopharmacology 4.47
J.P. Lépine1
Estimated H-index: 1
,
A. Pelissolo1
Estimated H-index: 1
Published on Jun 1, 1995in Journal of Pharmacology and Experimental Therapeutics 3.62
D M Thompson3
Estimated H-index: 3
,
James Auta15
Estimated H-index: 15
+ 1 AuthorsE. Costa40
Estimated H-index: 40
Imidazenil is a highly potent partial allosteric modulator of gamma-aminobutyric acid action at a great variety of gamma-aminobutyric acid(A) receptors, whereas alprazolam is a full allosteric modulator at these receptors. Data in rats indicate that imidazenil, like alprazolam, has pharmacological effects in animals indicative of anxiolytic, antipanic and anticonvulsant activity in humans, but unlike alprazolam, in animals imidazenil does not produce ataxia, sedation, tolerance or dependence nor...
Published on Jan 1, 1995in The Journal of Clinical Psychiatry 4.02
Steven Dubovsky40
Estimated H-index: 40
,
Marshall R. Thomas16
Estimated H-index: 16
The participation of serotonin (5-HT) in the regulation of diverse biological and psychological functions makes it possible for medications acting on 5-HT subsystems to play a role in the treatment of a growing number of psychiatric and medical disorders. The actions of new medications on the 5-HT reuptake mechanism are complemented by actions on the 5-HT receptors and on other neurotransmitter systems that may be effective in complex and treatment-resistant syndromes. New drugs acting on one or...
Cited By136
Newest
Published on Jun 17, 2019
Derya Özsavcı11
Estimated H-index: 11
(Marmara University),
Ozlem Bingol Ozakpinar7
Estimated H-index: 7
(Marmara University)
+ 1 AuthorsFeyza Aricioglu14
Estimated H-index: 14
(Marmara University)
Published on Jul 1, 2019in Journal of Chemical Neuroanatomy 2.36
Gwang-Ho Kim (SCH: Soonchunhyang University), Kyunghyun Lim (SCH: Soonchunhyang University)+ 15 AuthorsJong-Seok Moon3
Estimated H-index: 3
(SCH: Soonchunhyang University)
Abstract Recently, there have been reports that chronic insomnia acts as an insult in the brain, causing memory loss through the production of ROS, inflammation, and, Alzheimer’s disease if persistent. Insomnia remains the leading cause of sleep disturbance and as such has serious implications for public health. Patients with Alzheimer's disease are also known to suffer from severe sleep disturbance. Meanwhile, vitexin is a key ingredient in Passiflora incarnata L (passion flower, PF) extract, w...
Published on Jun 1, 2019in Integrative medicine research
David Casteleijn , Amie Steel15
Estimated H-index: 15
+ 2 AuthorsJon Wardle14
Estimated H-index: 14
Abstract Background Mental health conditions including anxiety and depression account for around 8% of the global disease burden. Anxiety and depression often coexist and impose a high individual and social burden. Patients with mental and behavioural conditions may be at increased risk of co-morbidities and are often high health-care utilisers. Herbal medicine is estimated to be used by up to 80% of the worlds population, and by 22% of Australian women seeking care for depression. The holistic ...
Published on Jan 1, 2019in Pharmaceutical Biology 2.49
Samantha Bedell (Campbell University), Jacob Wells (Campbell University)+ 1 AuthorsChris S. Breivogel3
Estimated H-index: 3
(Campbell University)
AbstractContext: Nicotine, a bioactive component of tobacco, is highly addictive. Numerous therapies have been developed for smoking cessation, and all have met with limited success. Our laboratory has previously shown that an extract of Passiflora incarnata Linn. (Passifloraceae) antagonized the expression of nicotine locomotor sensitization in rats.Objective: This study examined the ability of vitexin, a flavonoid found in P. incarnata, to ameliorate the signs of nicotine sensitization in rats...
Published on Jan 1, 2019
G. Mustafa (Jamia Hamdard), S. H. Ansari4
Estimated H-index: 4
(Jamia Hamdard)
+ 1 AuthorsA. S. Abdulkareim (Jamia Hamdard)
There have been many advancements in the treatment of generalized anxiety and post traumatic stress disorder. Attention to these disorders has increased with recent world events; however, continued efforts are needed to improve their diagnosis, treatment, and prevention. Objective of this review examines herbs commonly used for generalized anxiety and some other psychiatric symptoms and advantages associated with their use.
Published on Jul 1, 2018in Phytotherapy Research 3.77
Jerome Sarris28
Estimated H-index: 28
(USYD: University of Sydney)
Published on Jul 1, 2018in Journal of Nutrition Health & Aging 2.66
Owen T. Carmichael40
Estimated H-index: 40
(Pennington Biomedical Research Center),
Sreekrishna R. Pillai1
Estimated H-index: 1
(Pennington Biomedical Research Center)
+ 4 AuthorsJeffery N. Keller1
Estimated H-index: 1
(Pennington Biomedical Research Center)
Objectives To assess the effects of a combination of omega 3 essential fatty acids, green tea catechins, and ginsenosides on cognition and brain functioning in healthy older adults.
Published on May 1, 2018in Phytotherapy Research 3.77
K. Simon Yeung12
Estimated H-index: 12
(MSK: Memorial Sloan Kettering Cancer Center),
Marisol Hernandez4
Estimated H-index: 4
(MSK: Memorial Sloan Kettering Cancer Center)
+ 2 AuthorsJyothirmai Gubili8
Estimated H-index: 8
(MSK: Memorial Sloan Kettering Cancer Center)
Anxiety and depression are prevalent among cancer patients, with significant negative impact. Many patients prefer herbs for symptom relief to conventional medications which have limited efficacy/side effects. We identified single-herb medicines that may warrant further study in cancer patients. Our search included PubMed, Allied and Complementary Medicine, Embase, and Cochrane databases, selecting only single-herb randomized controlled trials between 1996 and 2016 in any population for data ext...
Published on Mar 1, 2018in Advances in Therapy 3.26
Hrvoje Barić2
Estimated H-index: 2
(University of Zagreb),
Veljko Đorđević6
Estimated H-index: 6
(University of Zagreb)
+ 1 AuthorsVladimir Trkulja15
Estimated H-index: 15
(University of Zagreb)
Introduction The objective was to evaluate efficacy/safety of complementary and alternative medicine (CAM) methods for generalized anxiety disorder (GAD) based on randomized controlled trials in adults.
Published on Jan 1, 2018in Phytotherapy Research 3.77
Karen Savage8
Estimated H-index: 8
(Swinburne University of Technology),
Joseph Firth24
Estimated H-index: 24
(University of Manchester)
+ 1 AuthorsJerome Sarris28
Estimated H-index: 28
(USYD: University of Sydney)