Match!

PASSIONFLOWER IN THE TREATMENT OF GENERALIZED ANXIETY: A PILOT DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL WITH OXAZEPAM

Published on Oct 1, 2001in Journal of Clinical Pharmacy and Therapeutics2.167
· DOI :10.1046/j.1365-2710.2001.00367.x
Shahin Akhondzadeh47
Estimated H-index: 47
(Tehran University of Medical Sciences),
Hamid Reza Naghavi10
Estimated H-index: 10
(Tehran University of Medical Sciences)
+ 3 AuthorsM. Khani6
Estimated H-index: 6
Sources
Abstract
Objective: Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder. Methods: The study was performed on 36 out-patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial. Results: Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam. Conclusion: The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage. A large-scale trial is justified.
  • References (26)
  • Citations (148)
📖 Papers frequently viewed together
74 Citations
121 Citations
308 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References26
Newest
#2Timothy A. BrownH-Index: 55
Since its inception as a diagnostic category in 1980, the definitional criteria for generalized anxiety disorder (GAD) have been revised substantially in each edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM). In DSM-III (American Psychiatric Association, 1980), GAD was a residual category (i.e., diagnosis was permitted only if criteria were not met for any other Axis I disorder); it was defined as the presence of generalized, persistent anxiety (continuous for a period ...
443 Citations
#1Hanns Möhler (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 73
#2Florence Crestani (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 24
Last. Uwe Rudolph (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 58
view all 3 authors...
The GABAA receptor is a pluripotent drug target mediating anxiolytic, sedative, anticonvulsant, muscle relaxant and amnesic activity. These drug actions have now been attributed to defined receptor subtypes. Thus, precise guidelines are available for the development of novel drugs with more selective action and less side effects than those currently in clinical use.
93 CitationsSource
#1Ashok K. Mehta (University of Texas Health Science Center at San Antonio)H-Index: 20
#2Maharaj K. Ticku (University of Texas Health Science Center at San Antonio)H-Index: 43
Recent advances in molecular biology and complementary information derived from neuropharmacology, biochemistry and behavior have dramatically increased our understanding of various aspects of GABAA receptors. These studies have revealed that the GABAA receptor is derived from various subunits such as α1–α6, β1–β3, γ1–γ3, δ, e, π, and ρ1–3. Furthermore, two additional subunits (β4, γ4) of GABAA receptors in chick brain, and five isoforms of the ρ-subunit in the retina of white perch (Roccus amer...
544 CitationsSource
#1Miriam Z. Mintzer (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 22
#2Roland R. Griffiths (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 73
Zolpidem is an imidazopyridine hypnotic with preferential binding affnity for the o1-benzodiazepine (BZD) receptor. The present double-blind, placebo-controlled study evaluated the effects of orally administered zolpidem (15 mg/70 kg) on specific memory functions in 16 healthy volunteers using a battery of word and picture memory tasks. Relative to placebo, zolpidem significantly impaired memory for material presented after drug administration when memory was assessed directly by referring subje...
40 CitationsSource
#1Shahin Akhondzadeh (Tehran University of Medical Sciences)H-Index: 47
#2Trevor Stone (Glas.: University of Glasgow)H-Index: 60
Abstract We have recently reported a new protocol for inducing long-term depression through activation of GABA A receptors in the hippocampal slices. This long-term depression is reversed by bicuculline and potentiated by neurosteroids such as alphaxalone. It was also shown that glutamate receptor activity or extracellular calcium are not involved in the induction of this type of long-term depression. The present study investigated the possible relation between muscimol-induced long-term depress...
13 CitationsSource
#1Craig R. Rush (UMMC: University of Mississippi Medical Center)H-Index: 14
Abstract Zolpidem, an imidazopyridine that purportedly binds selectively to certain GABA A receptor subtypes, is the most commonly prescribed hypnotic. The present article critically reviewed the extant experimental literature to determine whether the behavioral pharmacologic profile of zolpidem also differs from that of benzodiazepines. Specific topics that are reviewed include: 1) reinforcing effects and abuse potential, 2) discriminative-stimulus effects, 3) subject-rated drug effects, 4) per...
86 CitationsSource
#1Miriam Z. MintzerH-Index: 22
#2J. M. Frey (Johns Hopkins University)H-Index: 2
Last. Roland R. GriffithsH-Index: 73
view all 4 authors...
The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo
63 CitationsSource
1 CitationsSource
Imidazenil is a highly potent partial allosteric modulator of gamma-aminobutyric acid action at a great variety of gamma-aminobutyric acid(A) receptors, whereas alprazolam is a full allosteric modulator at these receptors. Data in rats indicate that imidazenil, like alprazolam, has pharmacological effects in animals indicative of anxiolytic, antipanic and anticonvulsant activity in humans, but unlike alprazolam, in animals imidazenil does not produce ataxia, sedation, tolerance or dependence nor...
23 Citations
The participation of serotonin (5-HT) in the regulation of diverse biological and psychological functions makes it possible for medications acting on 5-HT subsystems to play a role in the treatment of a growing number of psychiatric and medical disorders. The actions of new medications on the 5-HT reuptake mechanism are complemented by actions on the 5-HT receptors and on other neurotransmitter systems that may be effective in complex and treatment-resistant syndromes. New drugs acting on one or...
96 Citations
Cited By148
Newest
Last. Nguyen Thi Anh Tuyet (UEW: University of Education, Winneba)
view all 7 authors...
Source
Abstract The Hamilton Rating Scale for Anxiety (HAM-A) is one of the most widely used measures for assessing anxiety in research settings. However, it has been criticized for its inclusion of items that assess depressive symptoms. The DSM-5 Anxious Distress Specifier Interview (DADSI), developed as one assessment tool for measuring anxiety among depressed patients, demonstrates similar validity when compared with the HAM-A. However, its underlying factor structure has never been explored. The go...
Source
#1G Smilin Bell Aseervatham (Anna University)H-Index: 1
#1G. Smilin Bell Aseervatham (Anna University)H-Index: 1
Last. K. Ruckmani (Anna University)
view all 4 authors...
The anticonvulsant potential of aqueous fruit extract of Passiflora caerulea (PCAE) was evaluated in swiss albino mice induced by pilocarpine. The antioxidant activities of PCAE were determined which showed strong antioxidant activity and the polyphenol compounds such as ginsenoside, naringenin, chrysoeriol 8-c-glucoside, luteolin-6-C-glucoside, apigenin-6,8-di-C-β-D-glucopyranoside were profiled through RP-HPLC and UPLC-ESI-MS/MS. Chronic effects of PCAE on pilocarpine (85 mg/kg; i.p)-induced c...
Source
Abstract The aim of this study is the development of validated HPTLC method for the quantification of vitexin from Passiflora foetida commercial herbal formulations. The developed method was validated, in accordance with ICH guidelines for precision, accuracy, specificity and robustness. The plate was developed using ethyl acetate: methanol: water: formic acid 30: 4: 2: 1(%, v/v/v/v) on 20 × 10 cm glass coated silica gel 60 F254 plates and the developed plate was scanned and quantified densitome...
Source
#1Derya Özsavcı (Marmara University)H-Index: 11
#2Ozlem Bingol Ozakpinar (Marmara University)H-Index: 7
Last. Feyza Aricioglu (Marmara University)H-Index: 14
view all 4 authors...
Source
#1Gwang-Ho Kim (SCH: Soonchunhyang University)
#2Kyunghyun Lim (SCH: Soonchunhyang University)
Last. Sun Shin Yi (SCH: Soonchunhyang University)H-Index: 14
view all 18 authors...
Abstract Recently, there have been reports that chronic insomnia acts as an insult in the brain, causing memory loss through the production of ROS, inflammation, and, Alzheimer’s disease if persistent. Insomnia remains the leading cause of sleep disturbance and as such has serious implications for public health. Patients with Alzheimer's disease are also known to suffer from severe sleep disturbance. Meanwhile, vitexin is a key ingredient in Passiflora incarnata L (passion flower, PF) extract, w...
Source
#1David Casteleijn (UTS: University of Technology, Sydney)
#2Amie Steel (UTS: University of Technology, Sydney)H-Index: 16
Last. Jon Wardle (UTS: University of Technology, Sydney)H-Index: 14
view all 5 authors...
Abstract Background Mental health conditions including anxiety and depression account for around 8% of the global disease burden. Anxiety and depression often coexist and impose a high individual and social burden. Patients with mental and behavioural conditions may be at increased risk of co-morbidities and are often high health-care utilisers. Herbal medicine is estimated to be used by up to 80% of the worlds population, and by 22% of Australian women seeking care for depression. The holistic ...
Source
#1G. Mustafa (Jamia Hamdard)
#2Shahid H. Ansari (Jamia Hamdard)H-Index: 13
Last. A. S. Abdulkareim (Jamia Hamdard)
view all 4 authors...
There have been many advancements in the treatment of generalized anxiety and post traumatic stress disorder. Attention to these disorders has increased with recent world events; however, continued efforts are needed to improve their diagnosis, treatment, and prevention. Objective of this review examines herbs commonly used for generalized anxiety and some other psychiatric symptoms and advantages associated with their use.
Source
#1Samantha Bedell (Campbell University)
#2Jacob Wells (Campbell University)
Last. Chris S. Breivogel (Campbell University)H-Index: 3
view all 4 authors...
AbstractContext: Nicotine, a bioactive component of tobacco, is highly addictive. Numerous therapies have been developed for smoking cessation, and all have met with limited success. Our laboratory has previously shown that an extract of Passiflora incarnata Linn. (Passifloraceae) antagonized the expression of nicotine locomotor sensitization in rats.Objective: This study examined the ability of vitexin, a flavonoid found in P. incarnata, to ameliorate the signs of nicotine sensitization in rats...
Source
#1Jerome Sarris (USYD: University of Sydney)H-Index: 29
9 CitationsSource