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Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010

Published on Dec 1, 2013in Pediatric Research2.88
· DOI :10.1038/pr.2013.205
Hannah Blencowe44
Estimated H-index: 44
,
Joy E Lawn88
Estimated H-index: 88
+ 2 AuthorsClare Gilbert48
Estimated H-index: 48
Abstract
Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010
  • References (82)
  • Citations (175)
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References82
Newest
#1Devender RobertsH-Index: 12
#2Julie Brown (University of Auckland)H-Index: 32
Last. Stuart R Dalziel (University of Auckland)H-Index: 21
view all 4 authors...
Background Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial i...
1,398 CitationsSource
#1Hannah Blencowe (Lond: University of London)H-Index: 44
#2E. Theo Vos (UQ: University of Queensland)H-Index: 117
Last. Joy E LawnH-Index: 88
view all 8 authors...
Estimates of neonatal morbidities and disabilities at regional and global levels for 2010: introduction, methods overview, and relevant findings from the Global Burden of Disease study
65 CitationsSource
#1Hannah Blencowe (Lond: University of London)H-Index: 44
#2Anne C C Lee (Johns Hopkins University)H-Index: 34
Last. Joy E Lawn (Save the Children)H-Index: 88
view all 13 authors...
Background: In 2010, there were an estimated 15 million preterm births worldwide ( 90%) survive without neurodevelopmental impairment. Developing effective means of prevention of preterm birth should be a longer term priority, but major burden reduction could be made immediately with improved coverage and quality of care. Improved newborn care would reduce mortality, especially in low-income countries and is likely to reduce impairment in survivors, particularly in middle-income settings.
149 CitationsSource
#1Shahid Husain (QMUL: Queen Mary University of London)H-Index: 54
#2Ajay K. Sinha (QMUL: Queen Mary University of London)H-Index: 12
Last. Gillian G. W. Adams BSc Mb ChB (Moorfields Eye Hospital)H-Index: 19
view all 8 authors...
Objective To develop an algorithm that allows advanced identification of infants requiring treatment for retinopathy of prematurity (ROP). Study design A retrospective observational study was performed at 2 tertiary neonatal units serving a multiethnic population in the UK, using data on 929 infants eligible for ROP screening. The relationships between study variables and the risk of developing ROP requiring treatment were analyzed using multiple logistic regression. Results After applying exclu...
26 CitationsSource
#1Brian A. Darlow (University of Otago)H-Index: 45
#2Clare Gilbert (Lond: University of London)H-Index: 48
Last. Ana Quiroga (Austral University)H-Index: 4
view all 3 authors...
Retinopathy of prematurity (ROP) programs require collaboration between neonatologists, ophthalmologists, nurses, and allied health personnel, together with parents. The concept of a ROP program will vary according to the setting. However, in every situation there should be 2 main aspects: primary prevention of ROP through better overall care, and secondary prevention through case detection (often called screening), treatment, and follow-up. ROP programs will have different content and emphasis ...
21 CitationsSource
#1Clare M. Wilson (UCL Institute of Ophthalmology)H-Index: 11
#2Anna L. Ells (U of C: University of Calgary)H-Index: 21
Last. Alistair R. Fielder (Northampton Community College)H-Index: 45
view all 3 authors...
Screening for retinopathy of prematurity (ROP) and the optimum treatment of sight-threatening disease requires detailed understanding of the infants at risk and timely identification. Despite a plethora of guidelines, not all populations and situations are adequately covered, so that what should be preventable visual disability still occurs. This article considers the design of screening guidelines and the possibility of a global guideline, although in certain parts of the world manpower for ROP...
20 CitationsSource
#1Ben Stenson (Edin.: University of Edinburgh)H-Index: 21
#2William Tarnow-Mordi (USYD: University of Sydney)H-Index: 31
Last. Peter Brocklehurst Frcog (UCL: University College London)H-Index: 65
view all 28 authors...
Background The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that infants had reduced rates of retinopathy of prematurity when lower targets of oxygen saturation were used. Methods In three international randomized, controlled trials, we evaluated the effects of targeting an oxygen saturation of 85 to 89%, as compared with a range of 91 to 95%, on disability-free survival at 2 years in infants born before 28 weeks' gestation. Halfwa...
244 CitationsSource
#1Barbara SchmidtH-Index: 43
#2Robin K. WhyteH-Index: 23
Last. Robin S. Roberts ScDH-Index: 90
view all 8 authors...
Importance The goal of oxygen therapy is to deliver sufficient oxygen to the tissues while minimizing oxygen toxicity and oxidative stress. It remains uncertain what values of arterial oxygen saturations achieve this balance in preterm infants. Objective To compare the effects of targeting lower or higher arterial oxygen saturations on the rate of death or disability in extremely preterm infants. Design, Setting, and Participants Randomized, double-blind trial in 25 hospitals in Canada, the Unit...
220 CitationsSource
#1Brian A. Darlow (University of Otago)H-Index: 45
#2Anna L. EllsH-Index: 21
Last. Graham E. Quinn (Children's Hospital of Philadelphia)H-Index: 53
view all 5 authors...
The publication of the BEAT-ROP study of bevacizumab (Avastin) treatment for Zone I and II retinopathy of prematurity (ROP) has raised hopes that there might now be a simpler, cheaper and more effective treatment than laser therapy, the current standard of care. However, we would urge caution at this point in time. We review the scientific background to the use of intravitreal anti-vascular endothelial growth factor for ROP, highlight a number of design issues in the BEAT-ROP study and problems ...
76 CitationsSource
This article reviews retinopathy of prematurity, particularly regarding oxygen use, and describes current and potential therapies based on mechanistic studies in models relevant to current oxygen stresses in preterm infants.
191 CitationsSource
Cited By175
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#1Qingyu MengH-Index: 3
#2Yong ChengH-Index: 18
Last. Jianhong LiangH-Index: 6
view all 6 authors...
BACKGROUND: To evaluate the refractive outcomes in children treated with intravitreal injection of ranibizumab (IVR) for retinopathy of prematurity (ROP). METHODS: A retrospective study of 95 patients (186 eyes) was conducted. All patients received IVR treatment. The cycloplegic refraction was evaluated at three months, six months, 12 months and 24 months. RESULT: The average spherical equivalent (SE) refraction value for patients with ROP who were treated with IVR as a monotherapy at the three,...
Source
#1Gerd Holmström (Uppsala University)H-Index: 32
#2Ann Hellström (University of Gothenburg)H-Index: 43
Last. Eva Larsson (Uppsala University)H-Index: 18
view all 8 authors...
Background/aims During the last decade, improved neonatal care has resulted in increased survival of the most immature infants and improved health of more mature infants. We hypothesise that this has affected incidence and treatment of retinopathy of prematurity (ROP), enabling guidelines for screening to be modified. Methods In Sweden, all infants with gestational age (GA) at birth ≤30 weeks are screened for ROP. Results are registered in a web-based register, Swedish National ROP Register, wit...
1 CitationsSource
#1Chun-lin Zhang (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Candong Hong (HUST: Huazhong University of Science and Technology)H-Index: 4
Last. Bo Hu (HUST: Huazhong University of Science and Technology)H-Index: 21
view all 8 authors...
Abstract Small vessel diseases, such as ischemic retinopathy and cerebral small vessel disease (CSVD), are increasingly recognized in patients with diabetes, dementia and cerebrovascular disease. The mechanisms of small vessel diseases are poorly understood, but the latest studies suggest a role for semaphorins. Initially identified as axon guidance cues, semaphorins are mainly studied in neuronal morphogenesis, neural circuit assembly, and synapse assembly and refinement. In recent years, semap...
Source
#1Fares Antaki (Hôpital Maisonneuve-Rosemont)
#2Kenan Bachour (Université de Sherbrooke)
Last. Cynthia X. Qian (Hôpital Maisonneuve-Rosemont)
view all 4 authors...
Telemedicine-based remote digital fundus imaging (RDFI-TM) offers a promising platform for the screening of retinopathy of prematurity. RDFI-TM addresses some of the challenges faced by ophthalmologists in examining this vulnerable population in both low- and high-income countries. In this review, we studied the evidence on the use of RDFI-TM and analyzed the practical framework for RDFI-TM systems. We assessed the novel technological advances that can be deployed within RDFI-TM systems includin...
Source
Advanced therapy medicinal products (ATMPs) are the new frontier of medicine. Advanced therapy medicinal products are set out to satisfy unmet medical needs and provide new innovative, cutting-edge therapies for serious or life-threatening diseases, thus providing new therapeutic options for people with few or no possibility of treatment. They are divided into four groups including gene therapy medicinal products, cell-based therapy medicinal products, tissue-engineered products, and combined AT...
Source
#1Long Hin Li (HKU: University of Hong Kong)
#2Jetty Chung-Yung Lee (HKU: University of Hong Kong)H-Index: 13
Last. Amy C. Y. Lo (HKU: University of Hong Kong)H-Index: 30
view all 6 authors...
Lutein is one of the few xanthophyll carotenoids that is found in high concentration in the macula of human retina. As de novo synthesis of lutein within the human body is impossible, lutein can only be obtained from diet. It is a natural substance abundant in egg yolk and dark green leafy vegetables. Many basic and clinical studies have reported lutein’s anti-oxidative and anti-inflammatory properties in the eye, suggesting its beneficial effects on protection and alleviation of ocular diseases...
Source
#1Hannes Hudalla (University Hospital Heidelberg)H-Index: 5
#2Thomas Bruckner (Heidelberg University)H-Index: 47
Last. Ruben-J. Kuon (University Hospital Heidelberg)
view all 5 authors...
Retinopathy of prematurity (ROP) is a severe neonatal complication potentially leading to visual impairment and blindness. Known risk factors include preterm birth, low birth weight and respiratory support. Limited and contradictory data exist on the risk of maternal smoking during pregnancy on the development of ROP. This study aims to investigate smoking as an independent risk factor for the development of severe ROP (≥stage 3). This is a single centre retrospective case-control study of prosp...
Source
#1Se Joon Woo (Seoul National University Bundang Hospital)H-Index: 32
#2Jun Young Park (Seoul National University Bundang Hospital)
Last. Kyo Hoon Park (Seoul National University Bundang Hospital)H-Index: 17
view all 7 authors...
Purpose: To investigate whether elevated levels of inflammatory/angiogenic and growth mediators in amniotic fluid (AF) and the presence of intra-amniotic infection are associated with the occurrence and progression of retinopathy of prematurity (ROP) in preterm infants. Methods: This retrospective cohort study included 175 premature singleton infants who were born between 23+0 and 32+0 weeks. AF obtained via amniocentesis was cultured, and endoglin, endostatin, insulin-like growth factor-binding...
Source
AbstractObjective: To evaluate the visual outcomes after laser treatment for retinopathy of prematurity (ROP) among very-low-birth-weight neonates at 1-year corrected age in population of western I...
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#2Ayobami A. Bakare (UI: University of Ibadan)H-Index: 5
Last. Hamish Graham (Royal Children's Hospital)H-Index: 8
view all 10 authors...
Objective To evaluate the effectiveness of intermittent pulse oximetry in guiding oxygen therapy in neonates in a low-resource setting. Design and setting Prospective validation study at three hospitals in southwest Nigeria. We performed concealed continuous pulse oximetry on participants to evaluate intermittent SpO2 monitoring. Patients We recruited all preterm or low birthweight neonates, and all term neonates who required oxygen therapy, who were admitted to the neonatal ward(s) of the study...
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