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Effect of Endurance Exercise on Hepatic Lipid Content, Enzymes, and Adiposity in Men and Women

Published on Oct 1, 2008in Obesity3.97
· DOI :10.1038/oby.2008.358
Michaela C. Devries21
Estimated H-index: 21
(McMaster University),
Imtiaz A. Samjoo10
Estimated H-index: 10
(McMaster University)
+ 1 AuthorsMark A. Tarnopolsky93
Estimated H-index: 93
(McMaster University)
Cite
Abstract
Obesity and physical inactivity are independent risk factors for the development of nonalcoholic fatty liver disease (NAFLD). We determined the effect of endurance exercise training on hepatic lipid content and hepatic enzyme concentration in men and women. Waist circumference (WC), percent body fat (BF), computed tomography (CT) scans for liver attenuation (inverse relationship with hepatic lipid), bilirubin, alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT) plasma concentrations were measured before and after 12 weeks of endurance training in 41 lean and obese men and women. Exercise training did not change liver attenuation, body weight, percent BF, bilirubin, or ALT concentration, but did lower WC (P < 0.0001), and decreased GGT in men only (P = 0.01). Obese subjects had a lower liver attenuation than lean subjects (P = 0.04). Obese women had lower ALT than obese men (P = 0.03). GGT was lower in women before and after training. WC was positively correlated with GGT (r = 0.32, P = 0.003) and ALT (r = 0.320, P = 0.004) and negatively correlated with liver attenuation (r = –0.340, P = 0.03). Percent BF was negatively correlated with bilirubin (r = –0.374, P = 0.005). Liver attenuation was negatively correlated with ALT (r = –0.405, P = 0.003). Short-term endurance training without weight loss does not alter hepatic lipid content. There was a strong relationship between GGT/ALT and body composition (percent BF) as well as between ALT and hepatic lipid content.
  • References (75)
  • Citations (67)
Cite
References75
Newest
Published on Apr 1, 2007in Journal of Gastroenterology and Hepatology3.63
Mika Yamamoto8
Estimated H-index: 8
(Mie University),
Motoh Iwasa26
Estimated H-index: 26
(Mie University)
+ 7 AuthorsYukihiko Adachi40
Estimated H-index: 40
(Mie University)
Background: The pathogenesis of non-alcoholic steatohepatitis (NASH) is unclear. Recent studies suggested that oxidative stress plays an important role in the mechanism of NASH. Excessive accumulation of iron in the liver causes oxidative stress. The aim of the present study was to evaluate the grade of hepatic iron accumulation and the therapeutic response to restriction of calories, fat and iron in patients with non-alcoholic fatty liver disease (NAFLD). Methods: Twenty-seven NAFLD patients we...
Published on Apr 1, 2007in Journal of Gastroenterology and Hepatology3.63
Carlos K. Furuya6
Estimated H-index: 6
,
Claudia P. Oliveira20
Estimated H-index: 20
+ 8 AuthorsVenâncio Avancini Ferreira Alves21
Estimated H-index: 21
Background and Aim: Although nonalcoholic fatty liver disease (NAFLD) is very common among morbidly obese patients, the effect of weight loss after bariatric surgery on inflammation and fibrosis related to NAFLD is still a matter of debate. The aim of this study was to evaluate the impact of Roux-en-Y gastric bypass (RYGB) surgery on NAFLD with a follow up of 2 years. Methods: Eighteen consecutive NAFLD patients with body mass index >40 kg/m2 undergoing gastroplasty with RYGB were enrolled, and ...
Published on Apr 1, 2007in Indian Journal of Pediatrics1.14
Prashant Mathur12
Estimated H-index: 12
(ICMR: Indian Council of Medical Research),
Manoja Kumar Das6
Estimated H-index: 6
,
Narendra K. Arora3
Estimated H-index: 3
(AIIMS, New Delhi)
Obesity has emerged as a significant global health problem in the pediatric population. Pediatric liver disease is a serious complication of childhood obesity. Non-alcoholic steatohepatitis (NASH) is an entity in the spectrum of non-alcoholic fatty liver disease (NAFLD) ranges from fat in the liver — simple steatosis, NASH/ steatohepatitis — fat with in ammation and/or fibrosis to advanced fibrosis and cirrhosis when fat may no longer be present. NASH is associated with obesity, diabetes, insuli...
Published on Oct 1, 2006in Obesity Surgery3.60
John B. Dixon70
Estimated H-index: 70
,
Prithi S. Bhathal35
Estimated H-index: 35
,
Paul E. O’Brien64
Estimated H-index: 64
Background: The ability for aminotransferase levels to track histological features of non-alcoholic fatty liver disease (NAFLD) with weight loss has not been examined. Methods: We examined the effect of weight loss following laparoscopic adjustable gastric banding surgery on the histological features of NAFLD and plasma aminotransferase concentrations (AST, ALT and GGT) in 60 (12M, 48F) selected severely obese patients. All 120 paired biopsies were deidentified and scored for lobular steatosis, ...
Published on Sep 1, 2006in American Journal of Clinical Pathology1.96
Aus T. Ali9
Estimated H-index: 9
(National Health Laboratory Service),
Janice E. Paiker5
Estimated H-index: 5
(National Health Laboratory Service),
Nigel J. Crowther28
Estimated H-index: 28
(National Health Laboratory Service)
Alkaline phosphatase (ALP) is present in human preadipocytes. The aim of this study was to determine the relationship between anthropometry and serum levels of ALP isoenzymes, liver enzymes, albumin, and bilirubin. Anthropometric variables; serum total, bone, liver, and intestinal ALP levels; and alanine aminotransferase (ALT), albumin, total protein, total bilirubin, and γ-glutamyltransferase serum levels were measured in 100 volunteers. The levels (given as median [interquartile range]) for to...
Published on Aug 1, 2006in Hepatology14.97
Valerio Nobili49
Estimated H-index: 49
(Boston Children's Hospital),
Matilde Marcellini28
Estimated H-index: 28
(Boston Children's Hospital)
+ 5 AuthorsPaul Angulo69
Estimated H-index: 69
(Mayo Clinic)
Nonalcoholic fatty liver disease (NAFLD), a common cause of chronic liver disease in adults, is incompletely characterized in children. We conducted a prospective study to better characterize the clinical presentation of NAFLD in children and to determine the effect of lifestyle advice in the management of pediatric NAFLD. From June 2001 to April 2003, 84 children (age 3-18.8 yr) who had elevated aminotransferases and the diagnosis of NAFLD confirmed via liver biopsy underwent a 2-hour oral gluc...
Clinton R. Bruce42
Estimated H-index: 42
,
A. Brianne Thrush10
Estimated H-index: 10
+ 4 AuthorsDavid J. Dyck36
Estimated H-index: 36
Muscle fatty acid (FA) metabolism is impaired in obesity and insulin resistance, reflected by reduced rates of FA oxidation and accumulation of lipids. It has been suggested that interventions that increase FA oxidation may enhance insulin action by reducing these lipid pools. Here, we examined the effect of endurance training on rates of mitochondrial FA oxidation, the activity of carnitine palmitoyltransferase I (CPT I), and the lipid content in muscle of obese individuals and related these to...
Published on May 1, 2006in Postgraduate Medical Journal1.95
Leon A. Adams33
Estimated H-index: 33
,
Paul Angulo69
Estimated H-index: 69
Non-alcoholic fatty liver disease (NAFLD) is common and may progress to cirrhosis and its complications. The pathogenesis of steatosis and cellular injury is thought to be related mostly to insulin resistance and oxidative stress. Therefore, management entails identification and treatment of metabolic risk factors, improving insulin sensitivity, and increasing antioxidant defences in the liver. Weight loss and exercise improve insulin sensitivity. Bariatric surgery may improve liver histology in...
Published on Mar 1, 2006in Journal of Applied Physiology3.14
Lance E. Davidson19
Estimated H-index: 19
,
Jennifer L. Kuk29
Estimated H-index: 29
+ 1 AuthorsRobert S. Ross39
Estimated H-index: 39
To develop a protocol for measurement of liver fat using computed tomography (CT), we conducted a preliminary study with 118 men and 76 women to determine a readily identifiable vertebral landmark at which the CT image displayed both liver and spleen. Analysis of five landmarks revealed that the CT image obtained at the T12–L1 level simultaneously displayed the liver and spleen in 90% of the men and women. The T12–L1 protocol was cross-validated on a sample of 130 men and 113 women. In this samp...
Published on Jan 17, 2006in Canadian Medical Association Journal6.94
Peter T. Katzmarzyk81
Estimated H-index: 81
,
Caitlin Mason7
Estimated H-index: 7
Obesity places a substantial burden on public health in Canada, and people with more extreme levels of obesity are at substantially increased risk of premature death. In 2003, Health Canada issued updated guidelines for body weight classification in adults (available at [www.hc-sc.gc.ca/fn-an/
Cited By67
Newest
Published on Jan 31, 2019in Applied Physiology, Nutrition, and Metabolism3.46
Miss Kayleigh M Beaudry (UW: University of Waterloo), Kayleigh M. Beaudry (UW: University of Waterloo), Michaela C. Devries21
Estimated H-index: 21
(UW: University of Waterloo)
Women and men store lipid differently within the body with men storing more fat in the android region and women storing more fat in the gynoid region. Fat is predominately stored in adipose tissue ...
Nermeen El-Agroudy (TUD: Dresden University of Technology), Anica Kurzbach2
Estimated H-index: 2
(TUD: Dresden University of Technology)
+ -3 AuthorsDominik Pesta1
Estimated H-index: 1
(HHU: University of Düsseldorf)
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common liver disorder worldwide. Specifically, nonalcoholic steatohepatitis (NASH) and fibrosis pose an enormous burden for patients and health-care systems. In the absence of approved pharmacological therapies, effective lifestyle interventions for NAFLD, such as dietary strategies and exercise training, are currently the therapeutic strategies of choice. This review covers the influence of macronutrient quality and quantity (i.e., l...
Published on Mar 7, 2019in World Journal of Gastroenterology3.41
Peter Deibert24
Estimated H-index: 24
,
Adhara Lazaro1
Estimated H-index: 1
+ 7 AuthorsThomas de Lange10
Estimated H-index: 10
Published on Sep 2, 2018in Disease Markers2.76
Yuli Huang13
Estimated H-index: 13
(Southern Medical University),
Jianjin Luo1
Estimated H-index: 1
(Southern Medical University)
+ 5 AuthorsYunzhao Hu15
Estimated H-index: 15
(Southern Medical University)
Background. Serum gamma-glutamyltransferase (GGT) is a biomarker of hepatic disease. Recent studies have shown that GGT may also associate with the risk of coronary artery disease. However, the underlying mechanisms of this association are still unclear. Methods. This study included 216 young patients with acute coronary syndrome (aged ≤55years) and 227 age-matched controls with normal findings by coronary angiography or coronary computed tomography angiography. We use standard colorimetric tech...
Published on Aug 1, 2018in European Journal of Clinical Investigation2.78
Emilio Molina-Molina2
Estimated H-index: 2
(University of Bari),
Raquel Lunardi Baccetto2
Estimated H-index: 2
(University of Bari)
+ 3 AuthorsPieroPortincasa42
Estimated H-index: 42
(University of Bari)
Published on Aug 15, 2016in KAUMS Journal
Azam Moosavi-Sohroforouzani (Shahid Chamran University of Ahvaz), Mohsen Ganbarzadeh (Shahid Chamran University of Ahvaz)
Background: During recent decades exercise has emerged as a key adjuvant tool in the control of many diseases, including non-alcoholic fatty liver diseases (NAFLD). In addition, studies have demonstrated that different training protocols were effective in reducing the prevalence of the disorder and improving some liver metabolic functions. The purpose of this review was to summarize and analyze articles about the effects of aerobic and resistance training on insulin resistance and some biomarker...
Published on May 1, 2016in Biomedicine & Pharmacotherapy3.74
Damian Skrypnik5
Estimated H-index: 5
,
Marzena Ratajczak3
Estimated H-index: 3
+ 6 AuthorsPaweł Bogdański15
Estimated H-index: 15
Abstract Introduction Obesity is a risk factor of nonalcoholic fatty liver disease. Although the standard therapy for obesity involves physical exercise, well-planned studies of the changes in liver function in response to different exercise intensities in obese subjects are scarce. The aim of the present study was to examine a question of how does exercise mode affect the liver function. Material and methods 44 women with abdominal obesity were randomized into two exercise groups: endurance (gr...
Published on Mar 4, 2016in Tropical Journal of Pharmaceutical Research0.44
Po Uadia1
Estimated H-index: 1
(University of Benin),
Ko Orumwensodia1
Estimated H-index: 1
+ 2 AuthorsCbn Akpata1
Estimated H-index: 1
Purpose: To evaluate the effect of physical and flexibility exercise on plasma levels of some liver enzymes and biomolecules of young Nigerian adults. Methods: Participants were subjected to a 2-h daily continuous physical and flexibility exercise for 6 weeks. Pre- and post-exercise blood samples were obtained and the effect of exercise on plasma levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma glutamyl tra...
Published on Jan 1, 2016
Silvia Marinho Ferolla5
Estimated H-index: 5
(UFMG: Universidade Federal de Minas Gerais)
Non-alcoholic fatty liver disease (NAFLD) is worldwide epidemic. This clinical entity is closely related to metabolic syndrome. Majority of the patients are obese. Metabolic factors and genetics play important roles in the pathogenesis of this disorder. NAFLD encompasses a spectrum of disorders including benign macrovesicular hepatic steatosis, non-alcoholic steatohepatitis, fibrosis, hepatic cirrhosis and hepatocellular carcinoma. Is expected that it is became the most common indication of live...
Published on Nov 1, 2015in Medical Laboratory Journal
Fatemeh Islami (Golestan University)
Background and Objectives: Nonalcoholic fatty liver disease is the most common chronic liver disorder and is also currently considered as the hepatic manifestation of metabolic syndrome. Regular exercise training may decrease fatty liver disease complications, although its impact is not yet clear. This study aimed to evaluate the effects of six weeks of aerobic training on liver enzymes and other factors contributing to metabolic syndrome in young inactive women. Methods: In this quasi-experimen...