CRISPR–Cas system: a powerful tool for genome engineering
Abstract
Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Recent advances with the RNA-mediated Cas9 endonuclease derived from clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) systems have dramatically transformed our ability to specifically modify intact genomes of diverse cells and organisms. The CRISPR–Cas system...
Paper Details
Title
CRISPR–Cas system: a powerful tool for genome engineering
Published Date
Mar 18, 2014
Journal
Volume
85
Issue
3
Pages
209 - 218
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