Principal findings from a multicenter trial investigating the safety of follicular-fluid meiosis-activating sterol for in vitro maturation of human cumulus-enclosed oocytes

To evaluate the safety of applying follicular-fluid meiosis-activating sterol (FF-MAS) in vitro to immature human oocytes.Phase I bicenter, randomized, parallel-group, controlled, partially blinded trial.Third-level referral academic centers, including reproductive biology and genetics laboratories.Endocrinologically normal women with a medical indication for IVF or intracytoplasmic sperm injection, or healthy volunteers.Subjects were randomized...