Synthesis and bioactivity of novel sulfone derivatives containing 2,4-dichlorophenyl substituted 1,3,4-oxadiazole/thiadiazole moiety as chitinase inhibitors

Volume: 101, Issue: 1, Pages: 6 - 15
Published: Sep 1, 2011
Abstract
null null The paper reported the synthesis and antifungal properties and mechanism of action of a series of 2-substituted methylthio-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole/thiadiazole and their corresponding sulfones. The preliminary biological test showed these compounds exhibit moderate to good antifungal activity. Particularly, the compounds null 7g null and null 7c null inhibited mycelia growth by approximately 50% (EC 50 ) at...
Paper Details
Title
Synthesis and bioactivity of novel sulfone derivatives containing 2,4-dichlorophenyl substituted 1,3,4-oxadiazole/thiadiazole moiety as chitinase inhibitors
Published Date
Sep 1, 2011
Volume
101
Issue
1
Pages
6 - 15
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