RNase H2-Initiated Ribonucleotide Excision Repair
Abstract
Ribonucleotides are incorporated into DNA by the replicative DNA polymerases at frequencies of about 2 per kb, which makes them by far the most abundant form of potential DNA damage in the cell. Their removal is essential for restoring a stable intact chromosome. Here, we present a complete biochemical reconstitution of the ribonucleotide excision repair (RER) pathway with enzymes purified from Saccharomyces cerevisiae. RER is most efficient...
Paper Details
Title
RNase H2-Initiated Ribonucleotide Excision Repair
Published Date
Sep 28, 2012
Journal
Volume
47
Issue
6
Pages
980 - 986
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