Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS.

Volume: 35, Issue: 2, Pages: 185 - 193
Published: Feb 1, 2003
Abstract
Attenuation of reperfusion injury by growth factors has recently been linked to recruitment of phosphatidylinositol-3 kinase (PI3K) and protein kinase B (Akt), a pathway also linked to the phosphorylation of eNOS by bradykinin. We, therefore, hypothesised that bradykinin would limit infarct size when given as an adjunct to reperfusion.Using an isolated perfused mouse heart model of ischaemia/reperfusion injury, we show that 100 nmol/I...
Paper Details
Title
Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS.
Published Date
Feb 1, 2003
Volume
35
Issue
2
Pages
185 - 193
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