Structural insight into substrate specificity of human intestinal maltase-glucoamylase
Abstract
Human maltase-glucoamylase (MGAM) hydrolyzes linear alpha-1,4-linked oligosaccharide substrates, playing a crucial role in the production of glucose in the human lumen and acting as an efficient drug target for type 2 diabetes and obesity. The amino- and carboxyl-terminal portions of MGAM (MGAM-N and MGAM-C) carry out the same catalytic reaction but have different substrate specificities. In this study, we report crystal structures of MGAM-C...
Paper Details
Title
Structural insight into substrate specificity of human intestinal maltase-glucoamylase
Published Date
Oct 1, 2011
Journal
Volume
2
Issue
10
Pages
827 - 836
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