Pentavalent vanadium induces hepatic metallothionein through interleukin-6-dependent and -independent mechanisms

Volume: 228, Issue: 2-3, Pages: 162 - 170
Published: Dec 1, 2006
Abstract
Metallothionein (MT) is a low-molecular-weight cysteine-rich protein which has a high affinity for metals. The synthesis of MT is induced by heavy metals such as cadmium and zinc. However, little is known about the induction of MT by tetravalent or pentavalent metals. We investigated the induction of MT synthesis by a pentavalent vanadium compound in mice. Hepatic MT concentrations were increased by subcutaneous injection of ammonium...
Paper Details
Title
Pentavalent vanadium induces hepatic metallothionein through interleukin-6-dependent and -independent mechanisms
Published Date
Dec 1, 2006
Journal
Volume
228
Issue
2-3
Pages
162 - 170
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