The helix-loop-helix gene E2A is required for B cell formation
Abstract
Heterodimers between tissue-specific basic-helix-loop-helix proteins and the gene products of E2A play major roles in determining tissue-specific cell fate. To understand the broad role of E2A in development, we have generated E2A mutant mice following homologous recombination in embryonic stem cells. Homozygous mutant mice develop to full term without apparent abnormalities, but then display a high rate of postnatal death. The surviving mice...
Paper Details
Title
The helix-loop-helix gene E2A is required for B cell formation
Published Date
Dec 2, 1994
Journal
Volume
79
Issue
5
Pages
875 - 884
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