Optimization of cultivation conditions for fungichromin production from Streptomyces padanus PMS-702

Published on Jan 1, 2008in Journal of The Chinese Institute of Chemical Engineers
· DOI :10.1016/j.jcice.2007.11.006
Jiun-Yan Wu4
Estimated H-index: 4
(NCHU: National Chung Hsing University),
Jenn-Wen Huang9
Estimated H-index: 9
(NCHU: National Chung Hsing University)
+ 2 AuthorsYung-Chuan Liu24
Estimated H-index: 24
(NCHU: National Chung Hsing University)
Abstract A novel strain, Streptomyces padanus PMS-702, was employed to produce fungichromin (FC, a polyene macrolide antibiotic) in a shake flask cultivation. In comparing the effects of various carbon and nitrogen sources on PMS-702 cultivation, it was found that glucose and soybean meal medium yielded the highest FC within 2 days. Factors such as medium composition, cultivation temperatures, and initial pH were optimized for FC production with response surface methodology (RSM). The optimal cultural condition obtained is as follows: glucose 11.2 g/L, soybean meal 11.2 g/L, CaCO 3 0.46 g/L, temperature 31.7 °C, and an initial pH 5.5. Under these conditions, FC production reached 112 mg/L, about an increase of 2.86 times, as compared to results under basic conditions.
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