Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis
Abstract
We previously suggested that, in obese animals and humans, white adipose tissue inflammation results from the death of hypertrophic adipocytes; these are then cleared by macrophages, giving rise to distinctive structures we denominated crown-like structures. Here we present evidence that subcutaneous and visceral hypertrophic adipocytes of leptin-deficient (ob/ob and db/db) obese mice exhibit ultrastructural abnormalities (including calcium...
Paper Details
Title
Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis
Published Date
Sep 1, 2013
Journal
Volume
54
Issue
9
Pages
2423 - 2436
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