Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

Nature64.80
Volume: 467, Issue: 7311, Pages: 108 - 111
Published: Sep 2, 2010
Abstract
If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to deleterious chromosome rearrangements, which could ultimately lead to the tumour phenotype. DSB ends are resected in a 5' to 3' fashion in cells, to yield single-stranded DNA (ssDNA) for the recruitment of factors critical for DNA damage checkpoint activation and repair by homologous recombination. The resection process involves redundant pathways consisting...
Paper Details
Title
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae
Published Date
Sep 2, 2010
Journal
Volume
467
Issue
7311
Pages
108 - 111
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